CJC + IPA — ESTAMPA
PLATE 06 — REFERENCIAS

CJC-1295 Ipamorelin: Full Reference Index

Every quantitative claim on this site maps to a numbered citation. Twenty-two primary findings plus four recent-studies entries, with DOIs and PubMed URLs.

Read the research About this almanac
Wide cordel woodcut of twenty-two carved chapbook broadsides pinned on a string with gold woodcut stars and three sky-blue key-study markers, on deep jade green

EST. 07 — TWENTY-TWO BROADSIDES, TWENTY-TWO INDEXED FINDINGS

ESTAMPA 01 — ABOUT THIS INDEX

About This Citation Index

The CJC-1295 ipamorelin literature indexed on this site spans 1998–2025, covering human Phase I/II-context trials, rat and mouse pharmacokinetic studies, bone mineral content protocols, GI motility models, sleep architecture research, secretagogue class reviews, equine doping-control methods, and FDA-approved GHRH analog data (tesamorelin) as a class-level comparator.

Citations marked with a species note reflect the research context in which the data were collected. Human data are distinguished from rodent and multi-species studies throughout. Dose ranges and outcomes are attributed to the study and species; they are not prescriptive parameters for human use.

ESTAMPA 02 — PRIMARY FINDINGS (1–22)

Primary Research Findings

  1. Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91(12):4792-4797. DOI: 10.1210/jc.2006-1702 PMID: 17018654
  2. Jetté L, Léger R, Thibaudeau K, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058. DOI: 10.1210/en.2004-1286 PMID: 15817669
  3. Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. DOI: 10.1530/eje.0.1390552 PMID: 9849822
  4. Johansen PB, Nowak J, Skjaerbaek C, et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999;9(2):106-113. DOI: 10.1054/ghir.1999.9998 PMID: 10373343
  5. Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. DOI: 10.1152/ajpendo.00201.2006 PMID: 16822960
  6. Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009;19(6):471-477. DOI: 10.1016/j.ghir.2009.03.001 PMID: 19386527
  7. Johansen PB, Hansen KT, Andersen JV, Johansen NL. Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption. Xenobiotica. 1998;28(12):1243-1252. DOI: 10.1080/004982598238976 PMID: 9879640
  8. Andersen NB, Malmlöf K, Johansen PB, et al. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001;11(5):266-272. DOI: 10.1054/ghir.2001.0239 PMID: 11735244
  9. Svensson J, Lall S, Dickson SL, et al. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol. 2000;165(3):569-577. DOI: 10.1677/joe.0.1650569 PMID: 10828840
  10. Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. J Pharmacol Exp Ther. 2009;329(3):1110-1116. DOI: 10.1124/jpet.108.149211 PMID: 19289567
  11. Ho KY, Veldhuis JD, Johnson ML, et al. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J Clin Invest. 1988;81(4):968-975. DOI: 10.1172/JCI113450 PMID: 3127426
  12. Weikel JC, Wichniak A, Ising M, et al. Ghrelin promotes slow-wave sleep in humans. Am J Physiol Endocrinol Metab. 2003;284(2):E407-E415. DOI: 10.1152/ajpendo.00184.2002 PMID: 12388174
  13. Farhy LS, Veldhuis JD. Deterministic construct of amplifying actions of ghrelin on pulsatile growth hormone secretion. Am J Physiol Regul Integr Comp Physiol. 2005;288(5):R1649-R1663. DOI: 10.1152/ajpregu.00451.2004 PMID: 15718392
  14. Chapman IM, Bach MA, Van Cauter E, et al. Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab. 1996;81(12):4249-4257. DOI: 10.1210/jcem.81.12.8954023 PMID: 8954023
  15. Sigalos JT, Pastuszak AW, Allison A, et al. Growth Hormone Secretagogue Treatment in Hypogonadal Men Raises Serum Insulin-Like Growth Factor-1 Levels. Am J Mens Health. 2017;11(6):1752-1757. DOI: 10.1177/1557988317718662 PMID: 28830317
  16. Memdouh S, Gavrilović I, Ng K, et al. Advances in the detection of growth hormone releasing hormone synthetic analogs. Drug Test Anal. 2021;13(7):1233-1247. DOI: 10.1002/dta.3183 PMID: 34665524
  17. Smith RG, Thorner MO. Growth Hormone Secretagogues as Potential Therapeutic Agents to Restore Growth Hormone Secretion in Older Subjects to Those Observed in Young Adults. J Gerontol A Biol Sci Med Sci. 2023;78(6):975-983. DOI: 10.1093/gerona/glad022 PMID: 37325967
  18. Spooner LM, Olin JL. Tesamorelin: a growth hormone-releasing factor analogue for HIV-associated lipodystrophy. Ann Pharmacother. 2012;46(2):240-247. DOI: 10.1345/aph.1Q629 PMID: 22298602
  19. Lall S, Tung LY, Ohlsson C, Jansson JO, Dickson SL. Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues. Biochem Biophys Res Commun. 2001;280(1):132-138. DOI: 10.1006/bbrc.2000.4065 PMID: 11162489
  20. Cappola AR, Auchus RJ, El-Hajj Fuleihan G, et al. Hormones and Aging: An Endocrine Society Scientific Statement. J Clin Endocrinol Metab. 2023;108(8):1835-1874. DOI: 10.1210/clinem/dgad225 PMID: 37326526
  21. Tausendfreund O, Bidlingmaier M, Martini S, et al. Growth hormone treatment in aged patients with comorbidities: A systematic review. Growth Horm IGF Res. 2024;75:101584. DOI: 10.1016/j.ghir.2024.101584 PMID: 38489867
  22. Timms M, Ganio K, Forbes G, Bailey S, Steel R. An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma. Drug Test Anal. 2019;11(4):593-601. DOI: 10.1002/dta.2554 PMID: 30489688